Review: lactulose or lactitol may improve hepatic encephalopathy but may be less effective than antibiotics.
نویسنده
چکیده
منابع مشابه
Lactitol in the treatment of chronic hepatic encephalopathy: an open comparison with lactulose.
Lactulose is currently the drug of choice for the treatment of hepatic encephalopathy. It is, however, only available as a syrup which is contaminated with other sugars. Consequently patients may express aversion to its excessively sweet taste and many experience nausea because of its hyperosmolarity. Lactitol is a disaccharide analogue of lactulose which can be produced as a pure crystalline p...
متن کاملNon-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials.
OBJECTIVE To assess the effects of non-absorbable disaccharides (lactulose and lactitol) in patients with hepatic encephalopathy. DATA SOURCES Cochrane Hepato-Biliary Group controlled trials register, Cochrane Library, Medline, and Embase until March 2003; reference lists of relevant articles; authors and pharmaceutical companies. REVIEW METHODS Randomised trials that compared non-absorbabl...
متن کاملCurrent trends in the treatment of hepatic encephalopathy
Hepatic encephalopathy (HE) is a common reversible neuropsychiatric syndrome associated with chronic and acute liver dysfunction and significant morbidity and mortality. Although a clear pathogenesis is yet to be determined, elevated ammonia in the serum and central nervous system are the mainstay for pathogenesis and treatment. Management includes early diagnosis and prompt treatment of precip...
متن کاملNew strategies for treating hepatic encephalopathy.
blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy. Comment Hepatic encephalopathy (HE) is a serious neuro-psychiatric complication of both acute and chronic liver disease. Historically, the role of ammonia accumulation has dominated explanations of the patho-genesis of HE. However, evidence has emerged for a role of other concurrent factors such as inflammation , hypo...
متن کاملEffects of lactulose and lactitol on protein digestion and metabolism in conventional and germ free animal models: relevance of the results to their use in the treatment of portosystemic encephalopathy.
Protein digestion and metabolism have been studied in laboratory rats and miniature pigs to investigate the mechanisms of action of lactulose and lactitol when used in the treatment of patients with portosystemic encephalopathy. Lactulose (beta-D-galactopyranosyl-(1----4)-beta-D-fructofuranose) and lactitol (beta-D-galactopyranosyl-(1----4)-D-glucitol) increased the excretion of nitrogenous mat...
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ورودعنوان ژورنال:
- ACP journal club
دوره 141 3 شماره
صفحات -
تاریخ انتشار 2004